Article
Defective octamer-dependent transcription is responsible for silenced immunoglobulin transcription in Reed-Sternberg cells.
Blood - 15 May 2001
Theil J, Laumen H, Marafioti T, Hummel M, Lenz G, Wirth T, Stein H
Abstract excerpt
The absence of immunoglobulin (Ig) expression in B-cell-derived Hodgkin and Reed-Sternberg (HRS) cells of classical Hodgkin disease (cHD) was initially suggested to be caused by crippling mutations in the Ig promoter or coding region. More recent investigations have, however, challenged this concept. This study addressed the role of mutations in the Ig promoter region in HRS cells. Nine cases of cHD and 3...
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