Article
Regulation of immunoglobulin promoter activity by TFII-I class transcription factors.
The Journal of biological chemistry - 13 Feb 2004
Tantin Dean, Tussie-Luna Maria Isabel, Roy Ananda L, Sharp Phillip A
Abstract excerpt
The restriction of immunoglobulin variable region promoter activity to B lymphocytes is a well known paradigm of promoter specificity. Recently, a cis-element, located downstream of the transcription initiation site of murine heavy chain variable promoters, was shown to be critical for B cell activity and specificity. Here we show that mutation of this element, termed DICE (Downstream Immunoglobulin Control...
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