Article
Impaired vasorelaxant responses to natriuretic peptides in the stroke-prone phenotype of spontaneously hypertensive rats.
Journal of hypertension - 1 Feb 1998
Russo R, Vecchione C, Cosentino F, Natale A, Mele A F, Muscolo M, Savoia C, Ganten D, Rubattu S, Volpe M
Abstract excerpt
BACKGROUND: We have previously shown that a locus on rat chromosome 5, termed STR 2, co-localizes with the genes encoding atrial natriuretic and brain natriuretic peptides, and is closely linked to the development of strokes in rats of a F2 hybrid cohort obtained by crossing stroke-prone spontane...
Topics
- Animals
- Aorta, Thoracic
- Atrial Natriuretic Factor
- Carotid Artery, Internal
- Cerebrovascular Disorders
- Cyclic GMP
- Hypertension
- In Vitro Techniques
- Male
- Natriuretic Peptide, Brain
- Nerve Tissue Proteins
- Nitroglycerin
- Phenotype
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
- Vasodilation