Article
Impaired vasorelaxant responses to natriuretic peptides in the stroke-prone phenotype of spontaneously hypertensive rats.
Journal of hypertension - 1 Feb 1998
Russo R, Vecchione C, Cosentino F, Natale A, Mele A F, Muscolo M, Savoia C, Ganten D, Rubattu S, Volpe M
Abstract excerpt
BACKGROUND: We have previously shown that a locus on rat chromosome 5, termed STR 2, co-localizes with the genes encoding atrial natriuretic and brain natriuretic peptides, and is closely linked to the development of strokes in rats of a F2 hybrid cohort obtained by crossing stroke-prone spontaneously hypertensive rats and spontaneously hypertensive rats. We also demonstrated that there are significant...
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