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Article

Allelotype frequency of the thiopurine methyltransferase (TPMT) gene in Japanese.

Pharmacogenetics - 1 Apr 2001

Kumagai K, Hiyama K, Ishioka S, Sato H, Yamanishi Y, McLeod H L, Konishi F, Maeda H, Yamakido M

Abstract excerpt

Polymorphisms at three loci in the thiopurine methyltransferase (TPMT) gene are known to be responsible for azathioprine and 6-mercaptopurine (6MP) toxicity. Among them, only TPMT*3C variant allele with A719G mutation was found in 15/522 (2.9%; 17/1044 alleles; 1.6%) Japanese individuals including two homozygotes. The allele frequency was different from that in Caucasians, and investigation of TPMT polymorphisms...

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Source

Identifiers

PMID: 11337944
DOI: 10.1097/00008571-200104000-00012

Genes

TPMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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