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Article

Thiopurine S-methyltransferase gene polymorphism in Japanese patients with autoimmune liver diseases.

Liver international : official journal of the International Association for the Study of the Liver - 1 Feb 2007

Tamori Akihiro, Shinzaki Mayumi, Kosaka Saori, Hayashi Takehiro, Iwai Shuji, Enomoto Masaru, Habu Daiki, Sakaguchi Hiroki, Kawada Norifumi, Hino Masayuki, Shiomi Susumu, Nishiguchi Shuhei

Abstract excerpt

BACKGROUND AND AIM: Thiopurine S-methyltransferase (TPMT) genotypes or phenotypes may be a predictive factor for azathioprine-induced toxicities. We investigated the genotypic status of TPMT to evaluate the risk of azathioprine-related adverse effects in Japanese patients with different liver diseases, including autoimmune hepatitis (AIH). METHODS: 49 patients with AIH, 67 with primary biliary cirrhosis (PBC),...

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Source

Identifiers

PMID: 17241387
DOI: 10.1111/j.1478-3231.2006.01392.x

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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