Article
Detection assay of rare variants of the thiopurine methyltransferase gene by PCR-RFLP using a mismatch primer in a Japanese population.
Biological & pharmaceutical bulletin - 1 Sept 2000
Hiratsuka M, Inoue T, Omori F, Agatsuma Y, Kishikawa Y, Mizugaki M
Abstract excerpt
Thiopurine methyltransferase (TPMT) catalyzes the metabolism of important drugs such as 6-mercaptopurine, 6-thioguanine, and azathioprine. The identification and frequency distributions of several variant TPMT alleles (TPMT*2--*8) have been described recently in many ethnic groups. We have recently demonstrated that TPMT*3C is the most common allele in Japanese subjects; however, it remains to be elucidated...
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