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Article

Evolution of the CCR5 Delta32 mutation based on haplotype variation in Jewish and Northern European population samples.

Human immunology - 1 May 2001

Klitz W, Brautbar C, Schito A M, Barcellos L F, Oksenberg J R

Abstract excerpt

The chemokine receptor 5 (CCR5) serves as a fusion cofactor for macrophage-tropic strains of HIV-1. In addition, CCR5 has been shown to mediate the entry of poxviruses into target cells. Individuals homozygous for the Delta32 deletion-mutation have no surface expression of CCR5 and are highly protected against HIV-1 infection. To gain insights into the evolution of the mutation in modern populations, the...

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Source

Identifiers

PMID: 11334678
DOI: 10.1016/s0198-8859(01)00239-7

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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