Article
Distribution of the mutated delta 32 allele of the CCR5 gene in a Sicilian population.
International journal of immunogenetics - 1 Jun 2005
Sidoti A, D'Angelo R, Rinaldi C, De Luca G, Pino F, Salpietro C, Giunta D E, Saltalamacchia F, Amato A
Abstract excerpt
The CCR5 gene encodes a cell-surface chemokine receptor molecule that serves as a co-receptor for macrophage-tropic strains of human immunodeficiency virus type 1 (HIV-1). A mutation in this gene may alter the expression or the function of the protein product, thereby altering chemokine binding and/or signalling or HIV-1 infection of cells that normally express CCR5 protein. Individuals homozygous for a 32-bp...
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