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Article

Mdm2 promotes genetic instability and transformation independent of p53.

Molecular and cellular biology - 1 Aug 2008

Bouska Alyssa, Lushnikova Tamara, Plaza Silvia, Eischen Christine M

Abstract excerpt

Mdm2, a regulator of the tumor suppressor p53, is frequently overexpressed in human malignancies. Mdm2 also has unresolved, p53-independent functions that contribute to tumorigenesis. Here, we show that increased Mdm2 expression induced chromosome/chromatid breaks and delayed DNA double-strand break repair in cells lacking p53 but not in cells with a mutant form of Nbs1, a component of the Mre11/Rad50/Nbs1 DNA...

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Source

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Identifiers

PMID: 18541670
DOI: 10.1128/MCB.01584-07
PMCID: PMC2493369

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ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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