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Article

Characterization of two peptide epitopes on Mdm2 oncoprotein that affect p53 degradation.

Peptides - 1 Oct 2002

Balass M, Kalef E, Maya R, Wilder S, Oren M, Katchalski-Katzir E

Abstract excerpt

Phosphorylation of Mdm2, in response to DNA damage, resulted in prevention of p53 degradation in the cytoplasm as well as reduction of its binding with monoclonal antibody (mAb) 2A10. Using a 15-mer phage-peptide library, we identified two 2A10-epitopes on human Mdm2 (hdm2): at positions 255-266 (LDSEDYSLSEEG) and 389-400 (QESDDYSQPSTS). Synthetic peptides corresponding to the above sites, inhibit the binding of...

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Identifiers

PMID: 12383858
DOI: 10.1016/s0196-9781(02)00147-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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