Article
No association between polymorphism of serotonin transporter gene and depression in Parkinson's disease in Chinese.
Neuroscience letters - 22 May 2009
Zhang Jing-Lin, Yang Jing-Fang, Chan Piu
Abstract excerpt
Depressive symptoms affect 40% to 50% of Parkinson's disease (PD) patients, and adversely impact their quality of life. The decrease of serotonin (5-HT) in the synaptic cleft is commonly considered as the cause of depression. The reuptake of 5-HT released into the synaptic cleft is mediated by the 5-HT transporter (5-HTT). Many studies have focused on the relationship between the 5-HTT-linked polymorphic region...
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