Article
Genetic Insights into the Molecular Pathophysiology of Depression in Parkinson's Disease.
Medicina (Kaunas, Lithuania) - 13 Jun 2023
Angelopoulou Efthalia, Bougea Anastasia, Paudel Yam Nath, Georgakopoulou Vasiliki Epameinondas, Papageorgiou Sokratis G, Piperi Christina
Abstract excerpt
Background and Objectives: Parkinson's disease (PD) is a clinically heterogeneous disorder with poorly understood pathological contributing factors. Depression presents one of the most frequent non-motor PD manifestations, and several genetic polymorphisms have been suggested that could affect the depression risk in PD. Therefore, in this review we have collected recent studies addressing the role of genetic...
Topics
- Humans
- Parkinson Disease
- Catechol O-Methyltransferase
- Depression
- Polymorphism, Genetic
- Nerve Growth Factors
- Genetic Predisposition to Disease
- Aldehyde Dehydrogenase, Mitochondrial
- Serotonin Plasma Membrane Transport Proteins