Article
Serotonin transporter gene polymorphic element 5-HTTLPR increases the risk of sporadic Parkinson's disease in Italy.
European neurology - 1 Jan 2009
Albani Diego, Vittori Angelica, Batelli Sara, Polito Letizia, De Mauro Stefania, Galimberti Daniela, Scarpini Elio, Lovati Carlo, Mariani Claudio, Forloni Gianluigi
Abstract excerpt
Parkinson's disease (PD) is a neurodegenerative disorder causing muscular rigidity, resting tremor and bradykinesia. We conducted an association study assessing how PD risk in Italy was influenced by the serotonin transporter gene (SLC6A4) polymorphic region 5-HTTLPR, consisting of an insertion/deletion (long allele-L/short allele-S) of 43 bp in the SLC6A4 promoter region. The SLC6A4 promoter single nucleotide...
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