Article
Role in fast inactivation of conserved amino acids in the IV/S4-S5 loop of the human muscle Na+ channel.
Neuroscience letters - 16 Aug 1996
Mitrovic N, Lerche H, Heine R, Fleischhauer R, Pika-Hartlaub U, Hartlaub U, George A L, Lehmann-Horn F
Abstract excerpt
Since it has been shown that point mutations in the S4-S5 loop of the Shaker K+ channel may disrupt fast inactivation, we investigated the role of three conserved amino acids in IV/S4-S5 of the adult human muscle Na+ channel (L1471, S1478, L1482). In contrast to the K+ channel mutations, the anal...
Topics
- Amino Acid Sequence
- Conserved Sequence
- Homeostasis
- Humans
- Molecular Sequence Data
- Muscles
- Mutation
- Myotonia
- Patch-Clamp Techniques
- Potassium Channels
- Sodium Channels