Article
Lack of association between genetic polymorphism of CYP11B2 and hypertension in Japanese: the Suita Study.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Mar 2001
Tsujita Y, Iwai N, Katsuya T, Higaki J, Ogihara T, Tamaki S, Kinoshita M, Mannami T, Ogata J, Baba S
Abstract excerpt
Aldosterone synthase (CYP11B2) is a key enzyme in the biosynthesis of aldosterone. Recently, a polymorphism in the 5'-flanking region of the CYP11B2 gene [T(-344)C] has been reported to be associated with blood pressure and plasma aldosterone levels. We investigated the association between this polymorphism and hypertension in a large population-based sample of 4,000 Japanese. The genotype distribution in...
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