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CYP11B2 polymorphisms and home blood pressure in a population-based cohort in Japanese: the Ohasama study.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jan 2004

Matsubara Mitsunobu, Sato Tomomi, Nishimura Takuya, Suzuki Michiko, Kikuya Masahiro, Metoki Hirohito, Michimata Mari, Tsuji Ichiro, Ogihara Toshio, Imai Yutaka

Abstract excerpt

Genetic polymorphisms of the aldosterone synthase gene (CYP11B2) have been major targets of studies into the genetic factors involved in hypertension. We have identified three genetic variants of CYP11B2, -344C/T at the promoter region, a conversion in intron 2 from the CYP11B2 sequence to the CYP11B1 sequence, and R173K in exon 3, in the Japanese population. -344C/T and R173K were in complete linkage...

Topics

Aged
Arteriosclerosis
Blood Pressure
Blood Pressure Determination
Cohort Studies
Cytochrome P-450 CYP11B2
Female
Genotype
Humans
Hypertension

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Introns

Japan

Male

Middle Aged

Polymorphism, Genetic

Source

Identifiers

PMID: 15055249
DOI: 10.1291/hypres.27.1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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