A submicroscopic interstitial deletion of chromosome 14 frequently occurs adjacent to the t(14;18) translocation breakpoint in human follicular lymphoma.

doi:10.1002/gcc.2870060303

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Article

A submicroscopic interstitial deletion of chromosome 14 frequently occurs adjacent to the t(14;18) translocation breakpoint in human follicular lymphoma.

Genes, chromosomes & cancer - 1 Mar 1993

Zelenetz A D, Cleary M L, Levy R

Abstract excerpt

The t(14;18) chromosomal translocation characteristic of follicular lymphoma (FL) juxtaposes the immunoglobulin heavy chain locus (IGH) and the BCL2 proto-oncogene. The translocation can be readily detected as a non-germline Notl fragment resolved by pulsed-field gel electrophoresis. A benefit of...

Topics

Alleles
Base Sequence
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
Electrophoresis, Gel, Pulsed-Field
Genes, Immunoglobulin
Humans
Immunoglobulin Constant Regions
Immunoglobulin mu-Chains
Lymphoma, Follicular
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Proteins

Polymerase Chain Reaction

Proto-Oncogene Mas

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-bcl-2

Recombinant Fusion Proteins

Sequence Deletion

Source

Open in PubMed

Identifiers

PMID: 7682098
DOI: 10.1002/gcc.2870060303

Genes

IGH
BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7682098-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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