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Article

Postnatally elevated levels of insulin-like growth factor (IGF)-II fail to rescue the dwarfism of IGF-I-deficient mice except kidney weight.

Endocrinology - 1 Jan 2007

Moerth Corinna, Schneider Marlon R, Renner-Mueller Ingrid, Blutke Andreas, Elmlinger Martin W, Erben Reinhold G, Camacho-Hübner Cecilia, Hoeflich Andreas, Wolf Eckhard

Abstract excerpt

This study tested whether elevated levels of IGF-II in the postnatal period can rescue the dwarfism in IGF-I-deficient mice. Heterozygous Igf1 mutant mice [I(+/-) II(wt)] were crossed with heterozygous Igf1 mutant, phosphoenolpyruvate carboxykinase promoter IGF-II transgenic mice [I(+/-) II(tg)], and [I(+/+) II(wt)], [I(+/+) II(tg)], [I(-/-) II(wt)], and [I(-/-) II(tg)] offspring were investigated. IGF-II levels...

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Identifiers

PMID: 17008389
DOI: 10.1210/en.2006-0385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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