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Article

The variance for the disequilibrium coefficient in the individual Hardy-Weinberg test.

Biometrics - 1 Dec 1999

Chen J J, Thomson G

Abstract excerpt

It is of interest to detect the deviation from Hardy-Weinberg proportion (HWP) for a particular heterozygote. Hernández and Weir (1989, Biometrics 45, 53-70) suggested a disequilibrium coefficient approach and proposed a 1-d.f. chi2 test. This note derives the appropriate variance under the null hypothesis for performing this individual HWP test. Examples of applying the test to human genetic disease data are...

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Source

Identifiers

PMID: 11315081
DOI: 10.1111/j.0006-341x.1999.01269.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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