Variance estimation of allele-based odds ratio in the absence of Hardy-Weinberg equilibrium.

Abstract excerpt

In gene-disease association studies, deviation from Hardy-Weinberg equilibrium in controls may cause bias in estimating the allele-based estimates of genetic effects. An approach to adjust the variance of allele-based odds ratio for Hardy-Weinberg equilibrium deviation is proposed. Such adjustments have been introduced for estimating relative risks of genotype contrasts and differences in allele frequency;...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alleles
• Share to Case-Control Studies
• Share to Confidence Intervals