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Article

Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer.

Oncogene - 29 Mar 2001

Kim D H, Nelson H H, Wiencke J K, Christiani D C, Wain J C, Mark E J, Kelsey K T

Abstract excerpt

Death associated protein (DAP)-kinase is a 16 kDa calmodulin-dependent serine/threonine kinase that carries a death domain at its C-terminus. DAP-kinase functions as a positive mediator of apoptosis that is induced by interferon-gamma. Recent studies suggest that DAP-kinase is involved in tumor metastasis and that it can be inactivated by methylation of CpG islands in the promoter region of the gene in some human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11313923
DOI: 10.1038/sj.onc.1204302

Genes

DAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer.PMID 11313923Read ↗

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DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity.Semantic proximity Read ↗

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