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Article

Urothelial carcinomas arising in arsenic‐contaminated areas are associated with hypermethylation of the gene promoter of the death‐associated protein kinase

22 Oct 2007

Abstract excerpt

AIMS: The mechanisms of urothelial carcinogenesis in areas highly contaminated with arsenic remain unclear. The aim was to determine whether hypermethylation of death-associated protein kinase (DAPK) gene is associated with chronic arsenic exposure. METHODS AND RESULTS: The frequency of aberrant promoter methylation of DAPK in 17 urothelial carcinomas from an arsenic-contaminated area and 21 urothelial carcinomas...

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PMID: 17953697
DOI: 10.1111/j.1365-2559.2007.02871.x

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