Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers.

BMC cancer - 3 May 2007

Liu Yang, Gao Weimin, Siegfried Jill M, Weissfeld Joel L, Luketich James D, Keohavong Phouthone

Abstract excerpt

BACKGROUND: Epidemiological studies indicate that some characteristics of lung cancer among never-smokers significantly differ from those of smokers. Aberrant promoter methylation and mutations in some oncogenes and tumor suppressor genes are frequent in lung tumors from smokers but rare in those from never-smokers. In this study, we analyzed promoter methylation in the ras-association domain isoform A (RASSF1A)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to Calcium-Calmodulin-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Death-Associated Protein Kinases

Share to Genes, erbB-1

Share to Genes, p53

Share to Genes, ras

Share to Smoking

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 17477876
DOI: 10.1186/1471-2407-7-74
PMCID: PMC1877812

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers.PMID 17477876Read ↗

Similar DNA methylation pattern in lung tumours from smokers and never-smokers with second-hand tobacco smoke exposureSemantic proximity Read ↗

Gene promoter methylation assayed in exhaled breath, with differences in smokers and lung cancer patientsSemantic proximity Read ↗

Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer.Semantic proximity Read ↗

Clinical significance of DAPK promoter hypermethylation in lung cancer: a meta-analysisSemantic proximity Read ↗

Hypermethylation of the Death-Associated Protein (DAP) Kinase Promoter and Aggressiveness in Stage I Non-Small-Cell Lung CancerSemantic proximity Read ↗

Quantitative promoter hypermethylation analysis of RASSF1A in lung cancer: comparison with methylation-specific PCR technique and clinical significance.Semantic proximity Read ↗

Identification of Epigenetic Aberrant Promoter Methylation in Serum DNA Is Useful for Early Detection of Lung CancerSemantic proximity Read ↗

Promoter methylations of RASSF1A and p16 is associated with clinicopathological features in lung cancers.Semantic proximity Read ↗

DNA hypermethylation analysis in sputum for the diagnosis of lung cancer: training validation set approachSemantic proximity Read ↗

Methylation patterns and K-ras mutations in tumor and paired serum of resected non-small-cell lung cancer patients.Semantic proximity Read ↗

Relationship of Ras association domain family 1 methylation and K-ras mutation in primary non-small cell lung cancer.Semantic proximity Read ↗

Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.