Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plutonium targets the p16 gene for inactivation by promoter hypermethylation in human lung adenocarcinoma

4 Feb 2004

Abstract excerpt

Lung cancer from radon or (239)plutonium exposure has been linked to alpha-particles that damage DNA through large deletions and point mutations. We investigated the involvement of an epigenetic mechanism, gene inactivation by promoter hypermethylation in adenocarcinomas from plutonium-exposed workers at MAYAK, the first Russian nuclear enterprise established to manufacture weapons plutonium. Adenocarcinomas were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14742312
DOI: 10.1093/carcin/bgh096

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plutonium targets the p16 gene for inactivation by promoter hypermethylation in human lung adenocarcinomaPMID 14742312Read ↗

Asbestos exposure predicts cell cycle control gene promoter methylation in pleural mesotheliomaSemantic proximity Read ↗

Aberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesotheliomaSemantic proximity Read ↗

Promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene: more common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression.Semantic proximity Read ↗

The Current Understanding Of Asbestos-Induced Epigenetic Changes Associated With Lung CancerSemantic proximity Read ↗

Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional studySemantic proximity Read ↗

Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer.Semantic proximity Read ↗

CDKN2A/p16 inactivation mechanisms and their relationship to smoke exposure and molecular features in non-small-cell lung cancer.Semantic proximity Read ↗

Radiation-Stimulated Epigenetic Reprogramming of Adaptive-Response Genes in the Lung: An Evolutionary Gift for Mounting Adaptive Protection against Lung CancerSemantic proximity Read ↗

Similar DNA methylation pattern in lung tumours from smokers and never-smokers with second-hand tobacco smoke exposureSemantic proximity Read ↗

Recent progress and perspectives on the mechanisms underlying Asbestos toxicitySemantic proximity Read ↗

Homozygous deletion of p16INK4a and tobacco carcinogen exposure in nonsmall cell lung cancer.Semantic proximity Read ↗

Aberrant CpG island methylation of the p16INK4a and estrogen receptor genes in rat lung tumors induced by particulate carcinogensSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.