Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A heritable defect in IL-12 signaling in B10.Q/J mice. II. Effect on acute resistance to Toxoplasma gondii and rescue by IL-18 treatment.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2001

Yap G S, Ortmann R, Shevach E, Sher A

Abstract excerpt

This study documents a defect in IL-12-dependent IFN-gamma responses in a substrain (B10.Q-H2-(q)/SgJ) of B10.Q mice that manifests as an acute susceptibility to infection by the intracellular protozoan pathogen, Toxoplasma gondii. Despite robust systemic production of IL-12, infected B10.Q/J animals fail to mount an early IFN-gamma response after parasite inoculation. Genetic experiments revealed that the host...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Drug Synergism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Injections, Intraperitoneal

Share to Interferon-gamma

Share to Interleukin-12

Share to Interleukin-18

Share to STAT4 Transcription Factor

Share to Toxoplasmosis, Animal

Source

Identifiers

PMID: 11313414
DOI: 10.4049/jimmunol.166.9.5720

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A heritable defect in IL-12 signaling in B10.Q/J mice. II. Effect on acute resistance to Toxoplasma gondii and rescue by IL-18 treatment.PMID 11313414Read ↗

A heritable defect in IL-12 signaling in B10.Q/J mice. I. In vitro analysis.Semantic proximity Read ↗

Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii.Semantic proximity Read ↗

Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi.Semantic proximity Read ↗

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity.Semantic proximity Read ↗

Plasmodium chabaudi chabaudi:Differential Susceptibility of Gene-Targeted Mice Deficient in IL-10 to an Erythrocytic-Stage InfectionSemantic proximity Read ↗

Altered proinflammatory cytokine production and enhanced resistance to Trypanosoma congolense infection in lymphotoxin beta-deficient mice.Semantic proximity Read ↗

Genes from Chagas susceptibility loci that are differentially expressed in T. cruzi-resistant mice are candidates accounting for impaired immunity.Semantic proximity Read ↗

Toxoplasma gondii effector TgIST blocks type I interferon signaling to promote infectionSemantic proximity Read ↗

Genetic analysis of host resistance to intracellular pathogens: lessons from studies of Toxoplasma gondii infection.Semantic proximity Read ↗

Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP.Semantic proximity Read ↗

Regulation of interleukin-12 signalling during T helper phenotype development.Semantic proximity Read ↗

Genetic analysis of influences on survival following Toxoplasma gondii infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.