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Article

Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2000

Cai G, Radzanowski T, Villegas E N, Kastelein R, Hunter C A

Abstract excerpt

The capacity of IL-12 to stimulate T and NK cell production of IFN-gamma is required for resistance to Toxoplasma gondii. To identify the transcription factors involved in this mechanism of resistance, mice deficient in STAT4, a protein involved in IL-12 signaling, were infected with T. gondii and their immune responses were analyzed. STAT4-/- mice were unable to control parasite replication and died during the...

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Source

Identifiers

PMID: 10946290
DOI: 10.4049/jimmunol.165.5.2619

Genes

STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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