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MEK-Specific Inhibitor U0126 Blocks Spread of Borna Disease Virus in Cultured Cells

15 May 2001

Abstract excerpt

Borna disease virus (BDV) is a highly neurotropic virus that causes Borna disease, a virus-induced immune-mediated encephalomyelitis, in a variety of warm-blooded animals. Recent studies reported that BDV can be detected in patients with psychiatric disorders. BDV is noncytopathic, replicates in the nucleus of infected cells, and spreads intraaxonally in vivo. Upon infection of susceptible cultured cells, virus...

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PMID: 11312358
DOI: 10.1128/jvi.75.10.4871-4877.2001

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