Article

PI3Kγ pathway contributes to neuroinflammation and neuronal death induced by Zika virus infection

2024-12-22

Abstract excerpt

<h4>ABSTRACT</h4> Zika virus (ZIKV) is an emerging arbovirus belonging to the Flaviviridae family and Orthoflavivirus genus, with a pronounced tropism for the central nervous system (CNS), where it induces neuroinflammation and neuronal death. ZIKV is known to exploit host cellular mechanisms, including the activation of survival pathways such as the PI3K/AKT signaling cascade, to evade apoptosis and enhance its...

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Literature Corpus work: 25904cd3-e2aa-5eb8-acb7-a3dbeb31cb01
DOI: 10.1101/2024.12.20.629712

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