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Suppression of Astrovirus Replication by an ERK1/2 Inhibitor

29 May 2008

Abstract excerpt

Human astroviruses are nonenveloped, positive-sense single-strand RNA viruses associated with self-limiting diarrhea. Although they are recognized as a leading cause of disease in young children, the cellular factors involved in astrovirus replication are not well defined. The extracellular signal-regulated kinase (ERK) pathway has been shown to regulate many viral infections, but its role during astrovirus...

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PMID: 18508903
DOI: 10.1128/jvi.02193-07

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