Article
A Raf kinase inhibitor demonstrates antiviral activities both in vitro and in vivo against different genotypes of virulent Newcastle disease virus.
Antiviral research - 1 Sept 2016
Yin Renfu, Liu Xinxin, Zhang Pingze, Chen Yanyu, Xie Guangyao, Ai Lili, Xue Cong, Qian Jing, Bi Yuhai, Chen Jianjun, Sun Yuzhang, Stoeger Tobias, Ding Zhuang
Abstract excerpt
Newcastle disease (ND) is still one of the major plagues of birds worldwide. Combat actions are limited to vaccines, highlighting the urgent need for new and amply available antiviral drugs. Previous results have shown that Newcastle disease virus (NDV) downregulates the intracellular Raf kinase inhibitor protein (RKIP) expression for efficient replication, suggesting that this molecular may be a suitable target...
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