Article
MEK inhibition impairs influenza B virus propagation without emergence of resistant variants.
FEBS letters - 12 Mar 2004
Ludwig Stephan, Wolff Thorsten, Ehrhardt Christina, Wurzer Walter Jürgen, Reinhardt Jens, Planz Oliver, Pleschka Stephan
Abstract excerpt
Influenza A and B viruses are still a major worldwide threat. We demonstrate that influenza B virus infection induces signaling via the Raf/MEK/ERK cascade, a process required for efficient virus production. Expression of dominant-negative Raf and ERK mutants or treatment with a MEK inhibitor (U0126) strongly impaired viral propagation, while selective activation of the pathway resulted in increased virus titers....
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