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Article

RNA viruses and the mitogenic Raf/MEK/ERK signal transduction cascade

19 Aug 2008

Abstract excerpt

The Raf/MEK/ERK signal transduction cascade belongs to the mitogen-activated protein kinase (MAPK) cascades. Raf/MEK/ERK signaling leads to stimulus-specific changes in gene expression, alterations in cell metabolism or induction of programmed cell death (apoptosis), and thus controls cell differentiation and proliferation. It is induced by extracellular agents, including pathogens such as RNA viruses. Many DNA...

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PMID: 18713014
DOI: 10.1515/bc.2008.145

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