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Vemurafenib Inhibits Acute and Chronic Enterovirus Infection by Affecting Cellular Kinase Phosphatidylinositol 4-Kinase Type IIIβ.

Microbiology spectrum - 17 Aug 2023

Laajala Mira, Zwaagstra Marleen, Martikainen Mari, Nekoua Magloire Pandoua, Benkahla Mehdi, Sane Famara, Gervais Emily, Campagnola Grace, Honkimaa Anni, Sioofy-Khojine Amir-Babak, Hyöty Heikki, Ojha Ravi, Bailliot Marie, Balistreri Giuseppe, Peersen Olve, Hober Didier, Van Kuppeveld Frank, Marjomäki Varpu

Abstract excerpt

Enteroviruses are one of the most abundant viruses causing mild to serious acute infections in humans and also contributing to chronic diseases like type 1 diabetes. Presently, there are no approved antiviral drugs against enteroviruses. Here, we studied the potency of vemurafenib, an FDA-approved RAF kinase inhibitor for treating BRAFV600E mutant-related melanoma, as an antiviral against enteroviruses. We showed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37436162
DOI: 10.1128/spectrum.00552-23
PMCID: PMC10433971

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