Article
Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus.
Molecular microbiology - 1 Apr 2001
Nagaev I, Björkman J, Andersson D I, Hughes D
Abstract excerpt
Fusidic acid resistance resulting from mutations in elongation factor G (EF-G) of Staphylococcus aureus is associated with fitness costs during growth in vivo and in vitro. In both environments, these costs can be partly or fully compensated by the acquisition of secondary intragenic mutations. Among clinical isolates of S. aureus, fusidic acid-resistant strains have been identified that carry multiple mutations...
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