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Article

Mechanisms of fusidic acid resistance.

Biochemical Society transactions - 29 Aug 2025

González-López Adrián, Selmer Maria

Abstract excerpt

Fusidic acid (FA) is an antibiotic used to treat staphylococcal infections, particularly Staphylococcus aureus. It acts by inhibiting protein synthesis through locking elongation factor G (EF-G) to the ribosome. In S. aureus, there are three mechanisms of resistance. Mutations in the antibiotic target, EF-G (fusA), are common. These mutations affect the FA binding or the stability of the FA-locked state of EF-G...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40827472
DOI: 10.1042/BST20253064
PMCID: PMC12493156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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