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Article

Lovastatin and phenylacetate induce apoptosis, but not differentiation, in human malignant glioma cells.

Acta neuropathologica - 1 Mar 2001

Schmidt F, Groscurth P, Kermer M, Dichgans J, Weller M

Abstract excerpt

Induction of differentiation is an attractive approach to the management of infiltrative tumors such as malignant glioma. Here, we report that lovastatin and phenylacetate induce apoptosis, but fail to induce differentiation, in malignant glioma cell lines and untransformed rat astrocytes. Lovastatin and phenylacetate promote p21 accumulation but fail to induce cell cycle arrest. BCL-2 gene transfer inhibits...

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PMID: 11307620
DOI: 10.1007/s004010000254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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