Article
Inhibition of proliferation and induction of differentiation in medulloblastoma- and astrocytoma-derived cell lines with phenylacetate.
Journal of neurosurgery - 1 Oct 1995
Stockhammer G, Manley G T, Johnson R, Rosenblum M K, Samid D, Lieberman F S
Abstract excerpt
The authors investigated the effects of a nontoxic differentiation inducer, phenylacetate (PA), on neuroectodermal tumor-derived cell lines. Treatment of medulloblastoma (Daoy and D283 MED) and glioma (U-251MG, C6, and RG2) cell lines resulted in a dose-dependent decline in DNA synthesis and cell...
Topics
- Animals
- Astrocytoma
- Cell Differentiation
- Cell Division
- Cell Line
- DNA, Neoplasm
- Dose-Response Relationship, Drug
- ELAV Proteins
- G1 Phase
- Gene Expression Regulation, Neoplastic
- Glial Fibrillary Acidic Protein
- Humans
- Medulloblastoma
- Mice
- Nerve Tissue Proteins
- Neuroblastoma
- Neurofilament Proteins
- Neuroglia