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Article

APO2 ligand: a novel lethal weapon against malignant glioma?

1 May 1998

Abstract excerpt

APO2L (TRAIL) is a novel CD95L (Fas/APO-1-L) homologous cytotoxic cytokine that interacts with various receptors which transmit (DR4, DR5) or inhibit (DcR1, DcR2) an apoptotic signal. Here, we report that human glioma cell lines preferentially express mRNAs for agonistic death receptors DR4 (8/12) and DR5 (11/12) rather than the death-inhibitory decoy receptors DcR1 (4/12) and DcR2 (2/12). Ten of 12 cell lines...

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Identifiers

PMID: 9613612
DOI: 10.1016/s0014-5793(98)00409-8

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APO2 ligand: a novel lethal weapon against malignant glioma?PMID 9613612Read ↗

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