Article
Conversion of a radioresistant phenotype to a more sensitive one by disabling erbB receptor signaling in human cancer cells.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1998
O'Rourke D M, Kao G D, Singh N, Park B W, Muschel R J, Wu C J, Greene M I
Abstract excerpt
Inhibition of cell growth and transformation can be achieved in transformed glial cells by disabling erbB receptor signaling. However, recent evidence indicates that the induction of apoptosis may underlie successful therapy of human cancers. In these studies, we examined whether disabling oncopr...
Topics
- Apoptosis
- Brain Neoplasms
- Cell Division
- ErbB Receptors
- Gamma Rays
- Genes, p53
- Glioblastoma
- Humans
- Mutation
- Phenotype
- Radiation Tolerance
- Signal Transduction
- Tumor Cells, Cultured