Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Profound, durable and MGMT‐independent sensitivity of glioblastoma cells to cyclin‐dependent kinase inhibition

14 Dec 2018

Abstract excerpt

TG02 is a novel cyclin‐dependent kinase (CDK) inhibitor and thought to act mainly via CDK‐9 inhibition‐dependent depletion of short‐lived oncoproteins such as MCL‐1 or c‐MYC. We studied the activity of TG02 in 9 human long‐term glioma cell lines (LTC) and 5 glioma‐initiating cell lines (GIC) using various cell death assays in vitro and in the LN‐229 LTC and ZH‐161 GIC models in vivo. TG02 exhibits strong...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Glioma Diagnosis and Treatment
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30549269
DOI: 10.1002/ijc.32069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Profound, durable and MGMT‐independent sensitivity of glioblastoma cells to cyclin‐dependent kinase inhibitionPMID 30549269Read ↗

Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulationSemantic proximity Read ↗

Cyclin-dependent kinase inhibitors exert distinct effects on patient-derived 2D and 3D glioblastoma cell culture modelsSemantic proximity Read ↗

Targeted inhibition of the methyltransferase SETD8 synergizes with the Wee1 inhibitor adavosertib in restraining glioblastoma growthSemantic proximity Read ↗

Mechanism-based design of agents that selectively target drug-resistant gliomaSemantic proximity Read ↗

Antitumor Activity of NVP-BKM120—A Selective Pan Class I PI3 Kinase Inhibitor Showed Differential Forms of Cell Death Based on p53 Status of Glioma CellsSemantic proximity Read ↗

PARP Inhibition Restores Extrinsic Apoptotic Sensitivity in GlioblastomaSemantic proximity Read ↗

Multifaceted resistance of gliomas to temozolomide.Semantic proximity Read ↗

Depatuxizumab Mafodotin (ABT-414)-induced Glioblastoma Cell Death Requires EGFR Overexpression, but not EGFRY1068 Phosphorylation.Semantic proximity Read ↗

CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma CellsSemantic proximity Read ↗

Induction of G1 Cell Cycle Arrest in Human Glioma Cells by Salinomycin Through Triggering ROS-Mediated DNA Damage In Vitro and In VivoSemantic proximity Read ↗

Inhibition of Glioblastoma Growth by the Thiadiazolidinone Compound TDZD-8Semantic proximity Read ↗

Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.