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Assessment of K-ras, Smad4 and p53 gene alterations in colorectal metastases and their role in the metastatic process.

Oncology reports - 1 Dec 2004

Losi Lorena, Luppi Gabriele, Benhattar Jean

Abstract excerpt

To date there is no genetic marker that gives accurate information on the prognostic impact for patients with colorectal cancer. A particular clone, not detected in the tumor, could be responsible for the metastatic process. To overcome this problem, genetic alterations were analyzed in metastatic tissues from 58 patients who developed metastases after curative surgery for colorectal cancer. K-ras, p53 and Smad4...

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PMID: 15547741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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