Article
Microsatellite instability in squamous cell carcinoma of head and neck from the Indian patient population.
International journal of cancer - 15 May 2001
Chakrabarti S, Dasgupta S, Roy S, Bhar A, Sengupta A, Roy A, Ray K, Bhattacharyya N P, Roy B, Panda C K, Roychoudhury S
Abstract excerpt
Genomic instability in simple repeated sequences has been observed in several human cancers. We have analyzed 50 squamous cell carcinomas of the head and neck (SCCHN) and 5 pre-malignant severe dysplastic tissues from Indian patient populations for microsatellite instability in 18 different loci spread over eight different chromosomes. Among the tumors analyzed, 45% exhibited instability at two or more loci, and...
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