Article
Instability of short tandem repeats (microsatellites) in human cancers.
Nature genetics - 1 Feb 1994
Wooster R, Cleton-Jansen A M, Collins N, Mangion J, Cornelis R S, Cooper C S, Gusterson B A, Ponder B A, von Deimling A, Wiestler O D
Abstract excerpt
The allele sizes of polymorphic microsatellite repeats in DNA from human cancers were compared to normal DNA from the same patients. In 16 out of 196 paired samples (8%), we found evidence of an extra allele of a different size in the tumour which was not present in the normal DNA. Sequence analysis confirmed that the extra allele originates from the appropriate locus and that the size change is attributable to...
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