Article
Low incidence of microsatellite instability in patients with cervical carcinomas.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Oct 1998
Rodriguez J A, Barros F, Carracedo A, Mugica-van Herckenrode C M
Abstract excerpt
Alterations in microsatellite sequences have been reported in a variety of human cancers. Microsatellite instability is thought to reflect the inactivation of genes involved in DNA mismatch repair (MMR), which could predispose to the accumulation of further genetic errors in affected cells. Genomic instability in human cancers might also result from the inactivation of cell cycle controls such as the...
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