Article
Microsatellite mutation of type II transforming growth factor-beta receptor is rare in atherosclerotic plaques.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2001
Clark K J, Cary N R, Grace A A, Metcalfe J C
Abstract excerpt
A somatic mutation within a microsatellite polyA tract in the coding region of the type II transforming growth factor (TGF)-beta receptor gene was reported to occur in human atherosclerotic and restenotic lesions. This mutation occurs frequently in colorectal cancer with the replication error repair phenotype and results in loss of sensitivity to the growth inhibitory effects of TGF-beta in cells from the tumors....
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