Genetic instability and atherosclerosis: can somatic mutations account for the development of cardiovascular diseases?

doi:10.1002/1098-2280(2000)35:4<265::aid-em1>3.0.co;2-m

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Article

Genetic instability and atherosclerosis: can somatic mutations account for the development of cardiovascular diseases?

Environmental and molecular mutagenesis - 1 Jan 2000

Andreassi M G, Botto N, Colombo M G, Biagini A, Clerico A

Abstract excerpt

Several observations suggest that cancer and atherosclerosis may entail fundamentally common biological mechanisms. The accumulation of lipids and the proliferation of smooth muscle cells (SMCs) are the main histological features of sclerotic plaque formation. The most prominent theory concerning the pathophysiological mechanisms of atherosclerotic plaque formation is the "inflammatory response to injury"...

Topics

Animals
Arteriosclerosis
Humans
Mutation
Neoplasms
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 10861945
DOI: 10.1002/1098-2280(2000)35:4<265::aid-em1>3.0.co;2-m

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