Article
Regulation of differentiation to the infective stage of the protozoan parasite Leishmania major by tetrahydrobiopterin.
Science (New York, N.Y.) - 13 Apr 2001
Cunningham M L, Titus R G, Turco S J, Beverley S M
Abstract excerpt
A critical step in the infectious cycle of Leishmania is the differentiation of parasites within the sand fly vector to the highly infective metacyclic promastigote stage. Here, we establish tetrahydrobiopterin (H4B) levels as an important factor controlling the extent of metacyclogenesis. H4B levels decline substantially during normal development, and genetic or nutritional manipulations showed that low H4B...
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