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Article

Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts.

Experimental cell research - 1 May 2001

Chen Q M, Prowse K R, Tu V C, Purdom S, Linskens M H

Abstract excerpt

Normal human cells have a limited replicative potential and inevitably reach replicative senescence in culture. Replicatively senescent cells show multiple molecular changes, some of which are related to the irreversible growth arrest in culture, whereas others resemble the changes occurring during the process of aging in vivo. Telomeres shorten as a result of cell replication and are thought to serve as a...

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PMID: 11302695
DOI: 10.1006/excr.2001.5182

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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