Article
Monitoring DNA damage during cell senescence.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Nelson Glyn, von Zglinicki Thomas
Abstract excerpt
Cellular senescence is a state of irreversible cell cycle arrest, accompanied by and in most cases driven by a persistent DNA damage response (DDR), which may be activated by uncapped telomeres or other forms of DNA damage. DNA damage foci, therefore, are an important part of the signaling pathway that induces cell senescence. however, similar foci can also be observed in proliferating cells, for instance as a...
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