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Article

Oxidative DNA damage and senescence of human diploid fibroblast cells.

9 May 1995

Abstract excerpt

Human diploid fibroblast cells cease growth in culture after a finite number of population doublings. To address the cause of growth cessation in senescent IMR-90 human fibroblast cells, we determined the level of oxidative DNA damage by using 8-oxoguanine excised from DNA and 8-oxo-2'-deoxyguanosine in DNA as markers. Senescent cells excise from DNA four times more 8-oxoguanine per day than do early-passage...

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PMID: 7753808
DOI: 10.1073/pnas.92.10.4337

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